International School Twente (ISTwente) is governed by two local school boards, viz. Stichting Consent-Enschede and Stichting Het Stedelijk Lyceum. The board of Consent governs 36 state Primary schools in the Twente region. The Board of Het Stedelijk Lyceum governs 7 state Secondary schools in Enschede. The Boards work in close partnership with regard to their responsibilty for ISTwente.
ISTwente works closely with its two affiliated schools, the Prinseschool for primary and Het Stedelijk Lyceum for secondary.